Resistance to targeted therapy in mantle cell lymphoma -- ScienceDaily quoting : sciencedaily

"As shown in the past by Dr. Tao's group, mantle cell lymphoma cells depend on strong interactions with the microenvironment for progression. Some patients are now treated with ibrutinib, a daily pill that has been associated with significant positive response by lymphoma patients. Sotomayor and his research team wanted to understand the lymphoma cells and the mechanisms that allow them to develop resistance to the drug. Today some patients suffering with mantle cell lymphoma, a type of blood cancer, can be treated with a pill called Ibrutinib, forgoing conventional chemotherapy. This allowed the cancer cells to come back, in some cases as more aggressive.




But a new Tel Aviv University study finds that stem cell therapy may, in fact, harm heart disease patients. Patients with severe and end-stage heart failure have few treatment options available to them apart from transplants and "miraculous" stem cell therapy. After exploring the molecular pathway in mice, the researchers focused on cardiac stem cells in patients with heart disease. Faced with a worse survival rate than many cancers, many heart failure patients have turned to stem cell therapy as a last resort. Hope for improved cardiac stem cell therapyIn addition, the researchers also discovered the molecular pathway involved in the negative interaction between stem cells and the immune system as they isolated stem cells in mouse models of heart disease.

Lab-created antibody could hold the secret to making stem cell therapy safer

Excess reactive oxygen species production mediates monoclonal antibody-induced human embryonic stem cell death via oncosis, Cell Death and Differentiation (2017). Choo and his team are working to make stem cell treatments safer by creating antibodies that 'clean up' the pluripotent stem cells which fail to differentiate. Since the first human embryonic stem cells were isolated in 1998, scientists have edged closer to developing 'cell therapy' for humans. They then isolated the antibodies and tested their ability to search and destroy pluripotent stem cells in a culture dish. Now, A*STAR scientists have developed an antibody that could make stem cell therapy safer.


collected by :Lucy William

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