Early antiretroviral therapy linked with bone loss in patients with HIV -- ScienceDaily quoting : sciencedaily

Current HIV treatment guidelines now recommend initiating antiretroviral treatment (ART) at the time of diagnosis. An increased rate of bone loss may become important years later, in the setting of increased risk of fragility fracture." However, a new study has found that such early ART causes greater bone loss compared with deferring ART. It will be important to understand the long-term consequences of reductions in bone mineral density associated with ART and whether these reductions continue or stabilise with longer therapy. Although the study revealed a negative effect on bone density of immediate ART, the overall benefits of ART for preventing HIV transmission and adverse health outcomes prevail.




"Our study demonstrated that both tDCS and physical therapy are effective in improving the walking ability in patients with PD," Dr. Piravej and coauthors conclude. One group received a noninvasive brain stimulation technique called transcranial direct current stimulation (tDCS). In the future, the ability to provide "patient-specific stimulation" tDCS at home could offer additional advantages. In addition to showing a benefit of brain stimulation, the results suggest that physical therapy has benefits beyond symptom relief for patients with PD. They suggest that physical therapy could provide an alternative in "resource limited" settings without access to tDCS.

Bone loss in HIV patients linked to early antiretroviral therapy

June 26 (UPI) -- A recent study has found a link between early antiretroviral treatment, or ART, with an increased risk of bone loss in patients with HIV infection. Current HIV treatment guidelines recommend beginning ART at the time of diagnosis, however, researchers have found that early ART may cause greater bone loss compared to deferred ART. Researchers followed 399 participants for an average of 2.2 years, with 195 patients receiving immediate ART and 204 patients receiving deferred ART. "An increased rate of bone loss may become important years later, in the setting of increased risk of fragility fracture." The study, published today in the Journal of Bone and Mineral Research, showed a negative effect on bone density in patients who received immediate ART compared to those who received deferred ART.


collected by :Lucy William

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