"Repeat BCG vaccination appears to permanently turn on signature Treg genes, and the vaccine's beneficial effect on host immune response recapitulates decades of human co-evolution with myocbacteria, a relationship that has been lost with modern eating and living habits. "Researchers worldwide have been examining the benefits of Tregs, but Faustman said that existing therapies have struggled to achieve long-term results. However, with BCG able to restore Tregs, this provides a clearer picture as to how vaccination works to reset the immune system within type 1 diabetes.Faustman's team was the first to document type 1 diabetes reversal in mice and in a subsequent phase I trial demonstrated successful human clinical results who had received the BCG vaccination . The results of a new clinical trial testing a type 1 diabetes vaccine have been presented at the 75th Scientific Sessions of the American Diabetes Association The genetic vaccine bacillus Calmette-Guerin (BCG) has been shown to reverse advanced type 1 diabetes in mice, and could help to restore proper immune response to insulin-producing beta cells The findings of this FDA-approved clinical trial were presented by principal investigator Dr Denise Faustman, PhD, director of the Massachusetts General Hospital Immunobiology Laboratory.The BCG vaccine is based on a harmless strain of bacteria related to one that causes tuberculosis. Long-term data from the study is expected to be published later this year.Now a five-year, 150-person, phase II trial is enrolling to assess whether repeat BCG vaccination can improve or even reverse advanced type 1 diabetes in adults.Earlier this year Belgian biotech company, Imcyse, announced they will begin human trials across Europe of a separate type 1 diabetes vaccine, with results expected in 2018.
Clinical study shows new mechanism that BCG vaccine uses to reverse advanced type 1 diabetes
Additional information about the clinical trial, including information for potential participants and financial supporters, is available at http://www. "Many groups are looking at the ability of BCG vaccination to reverse autoimmunity," says Faustman, who is an associate professor of Medicine at Harvard Medical School. Interim results from a FDA-approved clinical trial testing the generic vaccine bacillus Calmette-Guérin (BCG) to reverse advanced type 1 diabetes are being presented at the 75th Scientific Sessions of the American Diabetes Association. Best known for its role in tuberculosis prevention, the BCG vaccine is based on a harmless strain of bacteria related the one that causes tuberculosis. The data demonstrate a potential new mechanism by which the BCG vaccine may restore the proper immune response to the insulin-secreting islet cells of the pancreas.
Type 1 diabetes is less common Type 1 diabetes is far less common, affecting around 10 per cent of adults with the disease. Experts suggest the rising rates of type 2 diabetes is due to the obesity epidemic – a key cause of type 2 diabetes. Getty Images 2 The BCG vaccine could reverse the effects of type 1 diabetes, new research claimsType 1 diabetes is an autoimmune disease, that prevents the body from producing insulin. Type 2 diabetes linked to obesity Type 2 diabetes is the more common form of the disease – accounting for between 85 and 95 per cent of all cases, according to Diabetes UK. The BCG jab could reset the immune system, to stop the underlying cause of the disease, new findings suggest.
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