thewire : declared in Cholesterol-Lowering Vaccine May Immunise People Against Heart Disease

They concluded that the vaccine might represent an effective approach for the treatment and even prevention of cardiovascular disease. Share this:TweetWhatsAppPrintMoreEmailPocketThe vaccine has shown promising results in mice, and researchers estimate that it will be available on the market by 2025. A vaccine against cardiovascular disease has not been not available until now – although that may soon change. But in the last 15 years or so, heart disease has taken the helm, becoming responsible for a quarter of all deaths every year. In the present study, researchers from Austria and The Netherlands evaluated a vaccine, dubbed AT04A anti-PCSK9, for its therapeutic potential to ameliorate or even prevent coronary heart disease in the APOE*3Leiden.CETP mouse model.

High Cholesterol Vaccine Could Cut Heart Disease Risk

Curbing the tide of coronary heart disease, heart attacks, and other cardiovascular conditions is no mean feat. But what if a vaccine could actually protect against one of the biggest contributors to heart disease, a.k.a high levels of "bad" LDL cholesterol ? And it could take years to determine if a similar approach can actually lower the country's astronomical heart disease rates. Heart disease is the leading cause of death in America. It kills more than 600,000 Americans every year, according to the Centers for Disease Control (CDC).


The AT04A vaccine triggers the production of antibodies against PCSK9—an enzyme that prevents your body from clearing LDL, or "bad" cholesterol, from your blood. So if the vaccine does come with that risk, experts would have to determine whether it outweighs the benefit of lowering cholesterol. Now, it's important to note that the study is still preliminary, and so far, the vaccine has only proven effective in mice. This shows that it's likely the cholesterol-reducing effects would be long-lasting, study author Günther Staffler said in a press release. But a phase 1 clinical trial—which involves humans—is currently under way to see if the results translate to people, too.


collected by :Lucy William

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