More volunteers needed to test new HIV vaccine stat : news24

It is aimed at determining if a new HIV HVTN 702 vaccine regimen is safe, tolerable and effective in the long run in preventing HIV infection among South African adults. The HVTN 702 trial was launched on December 1 last year. However, despite the administrative snag, the vaccine trials have been continuing. It's important for the community to understand and be clear about what it means to participate in a vaccine trial," Yola said. Researchers are also obliged to make sure that participants understand the safety requirements and give their consent, he said.




Credit: NIH Scientists at The Scripps Research Institute (TSRI) have made another important advance in HIV vaccine design. This vaccine candidate indeed prompted the immune system to produce antibodies that neutralized the corresponding clade C HIV strain when tested in non-human primates. "Clade C HIV strains are responsible for the majority of infections worldwide." Because this is the only antibody target on the surface of HIV, an effective HIV vaccine will have to trigger the body to produce antibodies to neutralize the virus by blocking these activities. The researchers finally had a map of the clade C glycoprotein.

Scientists jump hurdle in HIV vaccine design

This vaccine candidate indeed prompted the immune system to produce antibodies that neutralised the corresponding clade C HIV strain when tested in non-human primates. Because this is the only antibody target on the surface of HIV, an effective HIV vaccine will have to trigger the body to produce antibodies to neutralise the virus by blocking these activities. Solving the clade C structureHIV mutates rapidly, so there are countless strains of HIV circulating around the world. "Clade C HIV strains are responsible for the majority of infections worldwide."The scientists faced a big challenge: The clade C envelope glycoprotein is notoriously unstable and the molecules are prone to falling apart. The researchers finally had a map of the clade C glycoprotein.


collected by :Lucy William

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