Gene therapy skin grafts for obesity and diabetes quoting : bionews

Annabel SlaterA proof-of-concept study in mice has demonstrated how skin grafts could deliver gene therapy for obesity and diabetes. Compared to controls, the mice with modified GLP1 skin grafts put on less weight. He added that lab-grown skin grafts have been used clinically for some time to treat burns, and have been proven safe. They grew the skin stem cells into a skin organoid, and grafted them onto mice. The researchers used CRISPR to edit skin stem cells taken from newborn mice.




Then they inserted the gene into skin cells and grew those cells in culture. A University of Chicago-based research team has overcome challenges that have limited gene therapy and demonstrated how their novel approach with skin transplantation could enable a wide range of gene-based therapies to treat many human diseases. Using CRISPR, a tool for precise genetic engineering, they modified the GLP1 gene. Or it could function as a metabolic sink, removing various toxins."Skin progenitor cells have several unique advantages that are a perfect fit for gene therapy. Human skin is the largest and most accessible organ in the body.

New gene therapy through skin transplants can help improve treatments for Type-2 diabetes and obesity

A new form of gene therapy administered through skin transplants can help improve treatments for Type-2 diabetes and obesity, researchers have claimed. When high-fat diet was combined with doxycycline, the mice secreted GLP1 and gained less weight, suggesting that "cutaneous gene therapy for GLP1 secretion could be practical and clinically relevant". "We think this platform has the potential to lead to safe and durable gene therapy, in mice and we hope, someday, in humans, using selected and modified cells from skin," Wu added. The cells when transplanted onto mice showed the grafts increased insulin secretion and reversed weight gain from a high-fat diet, as well as overturned insulin resistance. Read more about 5 things scientists believe you can do to fight the 'fat' geneSource: IANSImage source: Shutterstock


collected by :Lucy William

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