Quadruple-dose flu vaccine lowers SNF residents' hospitalizations, largest study shows according to : Mc Knight's

Quadruple-dose flu Vaccine lowers SNF residents' hospitalizations, largest study showsShare this content:linkedingoogleEmailPrintThe high-dose vaccine contains four times as many antigens as the standard doseVaccines with four times the antigen of standard flu vaccines significantly decrease the risk of respiratory and all-cause hospitalizations during flu season, according to the largest nursing home study conducted to date on the effect of a high dose flu vaccine. All participants were on Medicare and received high-dose flu vaccines instead of standard doses. Respiratory illness hospitalizations decreased by 12.7%, and all-cause hospitalizations fell by 8.5% during the study period. Research was conducted on 38,000 nursing home residents 65 and older across 38 states. Study findings were published by researchers at the University Hospitals Cleveland Medical Center on Thursday in the journal The Lancet Respiratory Medicine.




The study of the M-001 vaccine candidate had two primary targets, BiondVax said: to check its safety and the cellular immune responses specific to influenza. BiondVax said it is now considering proceeding directly to testing the clinical efficacy of a vaccination with M-001 alone in a pivotal Phase 3 clinical trial, in light of "these encouraging clinical trial results" that confirmed previous study results, the company said. In the trial, clinical efficacy is to be assessed by measuring a reduction of flu illness rate and severity. These same findings were reported by the company in November, as preliminary results of the study. The primary safety results showed that M-001 has a good safety profile and is well tolerated, the company said in a statement.

High-dose flu vaccine reduces hospital visits for nursing home residents

So we asked if the high-dose vaccine also would work better than regular-dose vaccine in the population we consider least able to respond. For every 69 people given the high-dose vaccine vs. the standard-dose vaccine, one more person stayed out of the hospital during the flu season. Just under half the homes, 409 to be exact, administered the high-dose vaccine while the other 414 provided a standard dose. But a significant reduction in hospitalizations can still be a benefit, Gravenstein said, even though the high-dose vaccine is more expensive than the standard-dose vaccine. A large, randomized clinical trial tested whether a flu vaccine with four times the antigen of a standard vaccine could reduce the risk of hospitalization among those especially vulnerable seniors.


collected by :Lucy William

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